The Ever Given, one of the world's largest container ships, resumed its journey and left the Suez Canal on Wednesday, 106 days after becoming wedged across a southern section of the waterway for nearly a week and disrupting global trade.

The Ever Given started to head north in the late morning across the Great Bitter Lake, which separates two sections of the canal and where it had been moored with its Indian crew since being refloated on March 29...